MODAFINIL

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Modafinil is an oral drug that is used for improving wakefulness in patients with excessive sleepiness. It is similar to Armodafinil (Nuvigil). Like amphetamines, Modafinil promotes wakefulness by stimulating the brain. It may work by increasing the amount of dopamine (a chemical neurotransmitter that nerves use to communicate with each other) in the brain by reducing the reuptake of dopamine into nerves. Modafinil was approved by the FDA in December 1998.

Adrafinil (Modafinil) is used to promote wakefulness in patients with excessive sleepiness associated with narcolepsy, obstructive sleep apnea (in addition to treatment of the underlying obstruction), and shift work sleep disorder. Narcolepsy is a chronic disease of the brain and spinal cord characterized most commonly by a recurrent, uncontrollable desire to sleep. Shift work sleep disorder is a condition in which the normal rhythm of sleep is disturbed, often as a result of working at night. Sleep apnea is a condition where sleep is constantly interrupted at night because of pauses in breathing or shallow breathing usually due to obstruction of the upper airway.

Modafinil Star and Modafinil XLis a smart drug, belongs tonootropic communities. It enhances your cognitive function in a variety of ways (more on that in a second). There are plenty of smart drugs, but Modafinil stands in a class of its own for a few reasons:

  • It’s not a stimulant. Modafinil acts sort of like a stimulant, but it’s actually a eugeroic – a wakefulness-promoting agent. It doesn’t make you speedy or jittery like most classical stimulants do. Modafinil also doesn’t have a crash or withdrawal, the way many smart drugs do.
  • It’s not addictive. In fact, Modafinil can help people kick addictions.
  • It has few to no side effects. Modafinil is very safe. I’ve hacked my brain with neuro feedback so much that I don’t see much of a benefit from Modafinil now, but I took it every day for 10 years and saw no problems of any kind with it during that time.
  • It works. Really well. Have you ever seen the movie Limitless with Bradley Cooper? It’s based on Modafinil. This stuff gives you superhuman mental processing, with few to no downsides.

Unlike some smart drugs, there’s a good deal of evidence to back up the effects of Modafinil.

  • It has been shown to increase your resistance to fatigue and improve your mood.
  • In healthy adults, Modafinil improves “fatigue levels, motivation, reaction time and vigilance.”
  • A study published by the University of Cambridge found Modafinil to be effective at reducing “impulse response”, i.e., bad decisions.
  • Modafinil even improves brain function in sleep deprived doctors.
  • There is some evidence Modafinil only helps people with lower IQ, but after years of experimenting (and upgrading IQ), it doesn’t feel that way.

Modafinil is not addictive. It has a risk of abuse, however – some people use it to stay up for way too long, which will probably make you sick. There is an extremely rare condition (about 5 cases per million people[10]) called SJS, or Stevens-Johnson Syndrome, in which people with genetic susceptibility can develop a dangerous life threatening rash. SJS is most often triggered by antibiotics, followed by analgesics, cough and cold medication, NSAIDs, psych epileptics, and antigout drugs. Cocaine, phenytoin, and modafinil can trigger it.

Even though the risk is low, you might want to get a genetic test before you use any of those drugs, including Modafinil. If you have one of these SNPs, you may have an increased risk, and to have the lowest risk, there are a lot of drugs you should avoid including some basic antibiotics.

Modafinil has a number of benefits with a general conclusion being that you simply become a better and upgraded version of yourself. The benefits include improved cognitive function, increased focus, increased motivation, increase in productivity and general higher quality of life.

This of course has resulted in a widespread and ever-increasing popularity among the general population. Modafinil is therefore not an unknown drug on a global scale. Alone in the United States, it is estimated that more than 20% of students has experimented with Modafinil, which is why it is probably safe to say that a large number of students are using Modafinil as a continuous aid in scoring a high GPA.

Modafinil has actually existed since the late 70’s, which is why we have a significant track record that makes it somewhat legitimate, although not conclusive, to say that this drug doesn’t hold potential debilitating side effects in the long run. The truth is that Modafinil is hardly associated with any side effects at all. The only common side effect is headache, which is relatively rare (around 11% experience it).

Modafinil (Adrafinil) is a wake-fullness agent. Used to stay awake, be better focused, and to work better, modafinil has also been found to be a very effective cognitive enhancer that improves the power of decision-making. It is thought to work by affecting certain brain chemicals that control the sleep/wake cycle and has been shown to enhance wakefulness, attention capacity and vigilance.

First approved for excessive sleepiness caused by narcolepsy in 1998, the drug is now frequently prescribed off-label for a host of conditions from depression to multiple sclerosis. Some researchers say it might also be used successfully to treat attention deficit hyperactivity disorder (ADHD).

Modafinil could be “the first well-validated pharmaceutical nootropic agent” – making it the first “real example” of a smart drug that can genuinely help with exam preparation and similar tasks.

HOW TO USE MADAFINIL?

Modafinil reduces extreme sleepiness due to narcolepsy and other sleep disorders, such as periods of stopped breathing during sleep (obstructive sleep apnea). It is also used to help you stay awake during work hours if you have a work schedule that keeps you from having a normal sleep routine (shift work sleep disorder).

This medication does not cure these sleep disorders and may not get rid of all your sleepiness. Modafinil does not take the place of getting enough sleep. It should not be used to treat tiredness or hold off sleep in people who do not have a sleep disorder.

It is not known how modafinil works to keep you awake. It is thought to work by affecting certain substances in the brain that control the sleep/wake cycle.

Read the Medication Guide provided by your pharmacist before you start using modafinil and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

For narcolepsy, take this medication by mouth with or without food as directed by your doctor, usually once daily in the morning. Or, if your doctor directs you to, the total daily dose of modafinil may be divided into a morning dose and a noon dose.

For obstructive sleep apnea, take this medication by mouth with or without food as directed by your doctor, usually once daily in the morning. Continue your other treatment (such as the CPAP machine, mouth device) unless your doctor tells you to stop.

If you are using modafinil for shift work sleep disorder, take it by mouth with or without food as directed by your doctor, usually once a day 1 hour before you start your work shift.

The dosage is based on your medical condition and response to treatment. Take this medication regularly to get the most benefit from it.

If you suddenly stop using this medication, you may have withdrawal symptoms (such as shaking, sweating, chills, nausea, vomiting, confusion). To help prevent withdrawal, your doctor may lower your dose slowly. Withdrawal is more likely if you have used modafinil for a long time or in high doses. Tell your doctor or pharmacist right away if you have withdrawal.

When this medication is used for a long time, it may not work as well. Talk with your doctor if this medication stops working well.

Though it helps many people, this medication may sometimes cause addiction. This risk may be higher if you have a substance use disorder (such as overuse of or addiction to drugs/alcohol). Take this medication exactly as prescribed to lower the risk of addiction. Ask your doctor or pharmacist for more details.

Tell your doctor if your condition does not improve or if it worsens.

Modafinil comes as a tablet to take by mouth. It is usually taken once a day with or without food. If you are taking modafinil to treat narcolepsy or OSAHS, you will probably take it in the morning. If you are taking modafinil to treat shift work sleep disorder, you will probably take it 1 hour before the beginning of your work shift. Take modafinil at the same time every day. Do not change the time of day that you take modafinil without talking to your doctor. Talk to your doctor if your work shift does not begin at the same time every day.

Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take modafinil exactly as directed.

Modafinil may be habit-forming. Do not take a larger dose, take it more often, or take it for a longer period of time than prescribed by your doctor.

Modafinil may decrease your sleepiness, but it will not cure your sleep disorder. Continue to take modafinil even if you feel well-rested. Do not stop taking modafinil without talking to your doctor.

Modafinil should not be used in place of getting enough sleep. Follow your doctor's advice about good sleep habits. Continue to use any breathing devices or other treatments that your doctor has prescribed to treat your condition, especially if you have OSAHS.

DOSAGE OF MODAFINIL

Dosage in Narcolepsy and Obstructive Sleep Apnea (OSA):

The recommended dosage of Modafinil for patients with narcolepsy or OSA is 200 mg taken orally once a day as a single dose in the morning.

Doses up to 400 mg/day, given as a single dose, have been well tolerated, but there is no consistent evidence that this dose confers additional benefit beyond that of the 200 mg/day dose.

Dosage in Shift Work Disorder (SWD):

The recommended dosage of Modafinil for patients with SWD is 200 mg taken orally once a day as a single dose approximately 1 hour prior to the start of their work shift.

Dosage Modifications in Patients with Severe Hepatic Impairment:

In patients with severe hepatic impairment, the dosage of Modafinil should be reduced to one-half of that recommended for patients with normal hepatic function.

Use in Geriatric Patients:

Consideration should be given to the use of lower doses and close monitoring in geriatric patients.

STORAGE OF MODAFINIL

Modafinil tablets are available as follows:

100 mg: Each capsule-shaped, white to off white tablet is debossed with Modafinil on one side and “100 MG” on the other. NDC 63459-101-30 – Bottles of 30

200 mg: Each capsule-shaped, white to off white, scored tablet is debossed with Modafinil on one side and “200 MG” on the other. NDC 63459-201-30 – Bottles of 30

Store at 20°-25°C (68°-77°F).Store at room temperature. Store in a dry place. Do not store in a bathroom. Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets. Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.

For most healthy people, 30-50 mg of modafinil will be plenty. It lasts 6-8 hours; take it in the morning, with or without food. Modafinil is a prescription drug; you can talk to your doctor about it. There are places you can get it online.

The recommended dose is 200 mg once daily not to exceed 400 mg. It should be administered in the morning for treating narcolepsy or obstructive sleep apnea, and one hour prior to work in those with shift work disorder. It can be taken with or without food. The 400 mg dose may not be more effective than the 200 mg dose.

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

Store modafinil in a safe place so that no one else can take it accidentally or on purpose. Keep track of how many tablets are left so you will know if any are missing.

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community.

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach.

Benefits of Modafinil

Nicknamed “moda,” Modafinil has become a smart drug of choice for students who take it to stay awake and focused, and to be able to work better – even though it is not licensed for this use, and is often obtained illegally, without a prescription.

While it is still not totally clear how the drug works in the brain, users and researchers report that it improves attention, executive function, memory and learning, and also creativity. It is often compared to stimulants like Ritalin and Adderall that are both schedule II amphetamines for treating ADHD. Both generally produce a sense of euphoria and are often used by healthy individuals to improve concentration and focus when studying or working on large projects. However, while Ritalin and Adderall are stimulants that increase norepinephrine and dopamine levels in the brain, modafinil seems to slow the brain down by decreasing gamma-aminobutyric acid. Ironically this produces a stimulant effect, but it doesn’t produce any sense of euphoria.

The recent British study mentioned above and below states that modafinil is a “eugeroic” (a drug that improves wakefulness and makes one more alert) that directly increases the cortical levels of catecholamine in the brain and other internal organs. It also indirectly: (1) has the effect of “upregulating” cerebral serotonin, orexin, glutamate, and also histamine levels, and (2) decreases levels of cerebral gamma-amino-butrytic acid.

Recognizing that it is used widely “off-prescription” for the purpose of cognitive enhancement, the two researchers state that the desire to improve executive function is the primary aim of many users. More specifically, they state that users find they are able to select and manipulate information and use it to exclude irrelevant information and focus on what is required, initiating and constructing complex plans of action.

A growing number of students who need to learn a lot quickly swear by modafinil, saying it gives them the ability to work harder, longer. Various experiences have been shared. A user who takes the drug five days a week when studying says it makes him “feel like a well-oiled machine” for about five hours. Another says she finds she can type a lot faster. One states his brain is at “ninja level.” Others say they take it because their level of focus improves radically and this translates to good exam results.

INTERACTIONS OF MODAFINIL

Disease Interaction:

  • If you have an allergy to modafinil, Armodafinil, or any other part of modafinil.
  • If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
  • If you have ever had a rash when taking modafinil or a drug like it.
  • If you have heart valve problems.

This is not a list of all drugs or health problems that interact with modafinil. Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take modafinil with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

Drug Interactions: Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/non-prescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Some products that may interact with this drug include: street drugs (such as methamphetamine, MDMA/"ecstasy").

This medication may decrease the effectiveness of hormonal birth control such as pills, patch, or ring. This could cause pregnancy. Discuss with your doctor or pharmacist if you should use additional reliable birth control methods while using this medication and for 1 month after stopping this medication. Also tell your doctor if you have any new spotting or breakthrough bleeding, because these may be signs that your birth control is not working well.

Modafinil can speed up the removal of other medications from your body, which may affect how they work. Examples of affected drugs include:

  • Axitinib
  • Bosutinib
  • certain products used to treat chronic hepatitis C (asunaprevir, ombitasvir/paritaprevir/ritonavir), among others.

Some products have ingredients that could raise your heart rate or blood pressure. Tell your pharmacist what products you are using, and ask how to use them safely (especially cough-and-cold products or diet aids).

Caffeine can increase the side effects of this medication. Avoid drinking large amounts of beverages containing caffeine (coffee, tea, colas), eating large amounts of chocolate, or taking non-prescription products that contain caffeine.

Modafinil is very similar to Armodafinil. Do not take medications containing Armodafinil while using Modafinil.

PRECAUTIONS WHILE TAKING MODAFINIL

  • Tell all of your health care providers that you take modafinil. This includes your doctors, nurses, pharmacists, and dentists.
  • This medicine is not a cure for sleep problems. Stay under the care of your doctor.
  • Avoid driving and doing other tasks or actions that call for you to be alert until you see how modafinil affects you.
  • This medicine may be habit-forming with long-term use.
  • If you stop taking modafinil all of a sudden, you may have signs of withdrawal. Tell your doctor if you have any bad effects.
  • Has your blood pressure checked often? Talk with your doctor.
  • You may have some heart tests before starting modafinil. Talk with your doctor.
  • Avoid drinking alcohol while taking modafinil.
  • A very bad and sometimes deadly reaction has happened with modafinil. Most of the time, this reaction has signs like fever, rash, or swollen glands with problems in body organs like the liver, kidney, blood, heart, muscles and joints, or lungs. Talk with the doctor.
  • Limit your use of caffeine (for example, tea, coffee, cola) and chocolate. Use with modafinil may cause nervousness, shakiness, and a fast heartbeat.
  • If you are 65 or older, use modafinil with care. You could have more side effects.
  • This medicine is not approved for use in children. The chance of very bad and sometimes deadly skin reactions like Stevens-Johnson syndrome may be raised in children. However, your child's doctor may decide the benefits of taking modafinil may outweigh the risks. Talk with the doctor if you have questions about giving modafinil to your child.
  • Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using modafinil while you are pregnant.
  • Birth control pills and other hormone-based birth control may not work as well to prevent pregnancy. Use some other kind of birth control also, like a condom, when taking modafinil and for 1 month after care ends.
  • Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.

SIDE-EFFECTS OF MODAFINIL

Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of kidney problems like unable to pass urine, change in how much urine is passed, blood in the urine, or a big weight gain.
  • Signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-coloured stools, throwing up, or yellow skin or eyes.
  • Signs of low mood (depression), thoughts of killing yourself, nervousness, emotional ups and downs, thinking that is not normal, anxiety, or lack of interest in life.
  • Signs of heart problems like chest pain, fast heartbeat, a heartbeat that does not feel normal, or shortness of breath.
  • Hallucinations (seeing or hearing things that are not there).
  • Feeling confused.
  • Very bad headache.
  • Fever or chills.
  • Sore throat.
  • Swelling in the arms or legs.
  • Any unexplained bruising or bleeding.
  • Feeling very tired or weak.
  • Muscle or joint pain.

A very bad skin reaction (Stevens-Johnson syndrome/toxic epidermal necrolysis) may happen. It can cause very bad health problems that may not go away, and sometimes death. Get medical help right away if you have signs like red, swollen, blistered, or peeling skin (with or without fever); red or irritated eyes; or sores in your mouth, throat, nose, or eyes.

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

  • Nervous and excitable.
  • Headache.
  • Loose stools (diarrhoea).
  • Not able to sleep.
  • Back pain.
  • Dizziness.
  • Upset stomach.
  • Runny nose.
  • Stuffy nose.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

IS MODAFINIL SAFE FOR LONG-TERM USE?

Modafinil has emerged as the crown prince of smart drugs, that seductive group of pharmaceutical friends that promise enhanced memory, motivation, and an unrelenting ability to focus, all for hours at a time.

How does the drug work? It is believed that modafinil is a drug with multiple actions. This is because it acts on several neurotransmitter systems in the brain.

Neurotransmitters are the chemicals which transmit signals between cells in the brain. Modafinil definitely affects the dopamine system and dopamine will make you more alert, and also more interested in things. It affects norepinephrine which can again make you more alert and better able to focus, and it also affects histamine which can keep you awake.

But it is modafinil boost to the working memory that interests many, in particular students engaged in last-minute cramming. It is believed to enhance the short-term memory by as much as 10%, through its influence on a neurotransmitter called glutamate.

Long- term use may cause some serious side- effects. It should be used according to doctor’s consultation.

ALTERNATIVES OF MODAFINIL

Nootropics (Modafinil) – sometimes called smart drugs – are compounds that enhance brain function. They’re becoming a popular way to give your mind an extra boost. According to one Telegraph report, up to 25% of students at leading UK universities have taken the prescription smart drug modafinil, and California tech start-up employees are trying everything from Adderall to LSD to push their brains into a higher gear.

Here’s a list of 9 alternatives of Modafinil:

1. Modafinil (Provigil), Armodafinil (Nuvigil), and adrafinil – focus, motivation, clarity, memory

2. Nicotine- focus, mood, motivation

3. Amphetamine (Adderall)- focus, but with high risk and several drawbacks

4. L-theanine- calm alertness, reaction time, mental endurance

5. Bacopa Monnieri- attention, mood, stress, memory

6. Unfair Advantage- energy, clarity

7. KetoPrime- energy, stress

8. Forskolin & artichoke extract- memory, focus, learning

9. NeuroMaster- memory, focus

WHY MODAFINIL IS GAINING POPULARITY?

Nootropics (smart drugs) in general are gaining popularity, particular among younger people who need to focus, concentrate and improve their knowledge as quickly as possible. There are many different types, from nootropic peptides then there is modafinil, recently labelled the first real example of a genuine smart drug! One of the benefits of modafinil is that it isn’t a conventional stimulant, and reported side effects are minimal.

According to the federal Substance Abuse and Mental Health Services Administration, about 137,000 US college students abuse prescription stimulants every year. Ultimately, modafinil is a better bet than taking these, even though none of them is intended for use as a smart drug.

FAST FACTS ON MODAFINIL

  • Modafinil is a drug prescribed for the treatment of excessive sleepiness associated with narcolepsy, obstructive sleep apnea, and shift work sleep disorder.
  • Modafinil was approved by the FDA in December 1998.
  • It has some side- effects like headache, nausea, nervousness, insomnia, anxiety etc.
  • The recommended dose is 200 mg once daily not to exceed 400 mg
  • Modafinil can decrease or increase the activity of enzymes in the liver that metabolize (eliminate) other drugs.
  • Modafinil should be stored at room temperature, 15 C - 30 C (59 F - 86 F).

HOW TO BUY MODAFINIL ONLINE?

You can buy Modafinil at most store and online pharmacy. Depending on your location, the legality will vary depending how and where you can purchase Modafinil, and if you need a prescription. From what we have heard and seen, online pharmacies are the good places to start out if you are looking to purchase online. So, any sales questions or general inquiries you have will need to be directed to them.

There are plenty of sketchy online pharmacies that sell modafinil. Exercise caution when picking a particular vendor.

Modafinil Online is being sold on numerous websites, many of which are illegitimate. Buying from an unlicensed source puts your health at risk, so you should make sure you order from a trustworthy Modafinil Vendors. It is vital that you check whether the website you are using has been approved by the General Medical Council and that it is regularly reviewed by the Care Quality Commission. Stay away from remedies sold as Adrafinil Online - they do not work and they could be harmful to your health.

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